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Table 4 DEGs identified in KEGG pathway: Axon guidance. Differential expression indicates the average log2-fold change in RNA-Seq transcript levels from three independent experiments at each sampling period: D7 vs D0, D13 vs D7, D18 v D13, and D28 v D18. The p-values were ≤ 0.001. Negative log2-fold change corresponds to gene downregulation and the positive values indicate gene activation

From: Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation

Axon guidance
Gene ID Description Differential expression Time
NTNG1 netrin-G1 −2.536297436 D0-D7
DCC deleted in colorectal carcinoma 2.502983549 D0-D7
NTN1 netrin 1 3.198672486 D0-D7
FYN tyrosine-protein kinase Fyn 1.772436052 D0-D7
RGMA repulsive guidance molecule A 3.097407276 D0-D7
CXCR4 C-X-C chemokine receptor type 4 4.604478969 D0-D7
CXCL12 C-X-C motif chemokine 12 −4.220104913 D0-D7
EPHA3 Eph receptor A3 3.43500774 D0-D7
EPHA4 Eph receptor A4 1.860959561 D0-D7
EPHA7 EphA7 2.088277014 D0-D7
EPHB2 Eph receptor B2 1.873701283 D0-D7
EPHB3 Eph receptor B3 5.416063376 D0-D7
ENAH Enabled −0.89497636 D0-D7
SLIT1 slit 1 5.447826267 D0-D7
ROBO2 roundabout, axon guidance receptor 2 −2.472827128 D0-D7
NRP1 neuropilin 1 4.117109594 D0-D7
DPYSL5 dihydropyrimidinase-like 5 4.921620042 D0-D7
PTCH1 patched 1 3.517640353 D0-D7
BOC brother of CDO 4.811514207 D0-D7
BMP7 bone morphogenetic protein 7 3.232399315 D0-D7
BMPR1B bone morphogenetic protein receptor type-1B 1.78373296 D0-D7
DCC deleted in colorectal carcinoma 2.626762708 D7-D13
EPHA3 Eph receptor A3 2.836614823 D7-D13
PAK3 p21-activated kinase 3 1.64575883 D13-D18
NTNG1 netrin-G1 2.991377261 D13-D18
EPHA5 Eph receptor A5 3.15278798 D13-D18
SLIT1 slit 1 2.183813571 D13-D18
SLIT2 slit 2 2.342825102 D13-D18
NTNG1 netrin-G1 2.430765649 D18-D28
TRPC5 transient receptor potential cation channel subfamily C member 5 2.464006156 D18-D28
RGS3 regulator of G-protein signaling 3 −1.814236062 D18-D28
CXCL12 C-X-C motif chemokine 12 3.751564688 D18-D28
EPHA5 Eph receptor A5 3.524159164 D18-D28
EPHA6 Eph receptor A6 2.585950072 D18-D28
BOC brother of CDO −1.858286661 D18-D28
WNT4 wingless-type MMTV integration site family, member 4 2.873234122 D18-D28
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BMC Molecular and Cell Biology

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