Table 2 Predicted class memberships of the clinically abnormal biomarkers cut-off values for the 4 latent classes model. Estimated class population shares for the four different LCA classes
From: Metabolic profiles to predict long-term cancer and mortality: the use of latent class analysis
| LCA-derived Classes | Class 1 | Class 2 | Class 3 | Class 4 |
|---|---|---|---|---|
| % on the population | 63% | 22% | 9% | 6% |
| Biological interpretation | Normal | Lipids | Liver | Iron/ Inflammation |
| ApoB/ApoA-I ≥ 1.00 b | 0.1320 | 0.6840 | 0.4519 | 0.2480 |
| Log (Triglycerides/HDL) ≥ 0.50 b | 0.0126 | 0.5436 | 0.3852 | 0.1421 |
| Glucose ≥6.11 mmol/L | 0.0342 | 0.2401 | 0.2174 | 0.0919 |
| Fructosamine ≥2.60 mmol/L | 0.0039 | 0.0967 | 0.0555 | 0.0280 |
| ALT ≥50 IU/L | 0.0051 | 0.0107 | 1.0000 | 0.0291 |
| GGT Elevated36–72 IU/L | 0.0848 | 0.2532 | 0.3521 | 0.1732 |
| GGT Highly elevated ≥72 IU/L | 0.0240 | 0.0843 | 0.4098 | 0.0619 |
| AST ≥ 45 IU/L | 0.0052 | 0.0045 | 0.3168 | 0.0180 |
| CRP > 10 mg/L | 0.0282 | 0.0715 | 0.0771 | 0.2740 |
| Albumin < 35 g/L | 0.0007 | 0.0022 | 0.0024 | 0.0114 |
| Leukocytes ≥109 cells/L | 0.0265 | 0.0786 | 0.0438 | 0.1344 |
| Iron low μmol/L | 0.0001 | 0.0040 | 0.0281 | 0.5527 |
| Iron high μmol /L | 0.0404 | 0.0155 | 0.0712 | 0.0000 |
| TIBC low mg/dL | 0.2201 | 0.2807 | 0.2622 | 1.0000 |
| TIBC high mg/dL | 0.2438 | 0.1707 | 0.2984 | 0.0000 |
| Creatinine low μmol /L | 0.0022 | 0.0037 | 0.0041 | 0.0051 |
| Creatinine high μmol /L | 0.0822 | 0.1765 | 0.1166 | 0.1116 |
| Phosphate low mmol/L | 0.0078 | 0.0041 | 0.0063 | 0.0098 |
| Phosphate high mmol/L | 0.0425 | 0.0611 | 0.0544 | 0.1110 |
| Calcium low mmol/L | 0.0124 | 0.0092 | 0.0099 | 0.0458 |
| Calcium high mmol/L | 0.0121 | 0.0253 | 0.0299 | 0.0135 |