Interleukin-1α enhances the aggressive behavior of pancreatic cancer cells by regulating the α6β1-integrin and urokinase plasminogen activator receptor expression

Table 1 Alteration of integrin subunits and uPAR in pancreatic cancer cells in response to IL-1α

Antigen	IL-1α	Mean fluorescence intensity
		BxPC-3	Capan-2	SW1990
α₃integrin	-	310 ± 18	350 ± 12	411 ± 14
	+	383 ± 34^a	344 ± 18	399 ± 16
α₅integrin	-	40 ± 6	72 ± 9	60 ± 8
	+	44 ± 4	68 ± 8	61 ± 6
α₆integrin	-	520 ± 21	230 ± 11	441 ± 18
	+	833 ± 44^a	344 ± 27^a	612 ± 32^a
α_v integrin	-	77 ± 8	61 ± 9	51 ± 8
	+	71 ± 7	65 ± 9	58 ± 6
β₁integrin	-	997 ± 42	814 ± 31	810 ± 33
	+	1229 ± 41^a	1183 ± 22^a	1322 ± 24^a
uPA	-	34 ± 3	42 ± 2	51 ± 5
	+	143 ± 10^a	166 ± 13^a	191 ± 9^a
uPAR	-	219 ± 17	299 ± 31	291 ± 18
	+	423 ± 26^a	588 ± 21^a	524 ± 19^a

IL-1α, interleukin-1α; uPA, urokinase plasminogen activator; uPAR, urokinase plasminogen activator receptor. All data are expressed as mean ± s.d. The p-values indicate statistical significance between data in controls and presence of IL-α. ^a p < 0.01.

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